8 UROLOGY, URO-ONCOLOGY AND SEXOLOGY UPDATE This article is a summary of the article: “Evaluation of usefulness of propiverine hydrochloride in poor responders to previous anticholinergics.” By Naoya Masumori, Yuya Funato, Yasunobu Yamaguchi and Kunio Itoh. Published in LUTS (2018) 10, 116–12. Anticholinergic therapy is a popular treatment option for pollakisuria/urinary incontinence. There are a number of anticholinergics available but not all patients respond well to treatment. Propiverine hydrochloride has anticholinergic activity and calcium antagonistic activity. It has proven efcacy and a good safety prole for overactive bladder when compared with placebo. It has also been shown to be effective in a randomized controlled trial to treat benign prostatic hyperplasia with overactive bladder using an alpha-blocker combined with propiverine hydrochloride. In a previous study evaluating the usefulness of propiverine hydrochloride in poor responders to other anticholinergics, the overactive bladder symptom score (OABSS) was signicantly improved. However, the study involved only 73 subjects, so the authors designed this survey to validate these results in a much larger sample size. Methods Eligibility criteria In this survey 3851 subjects at 680 institutions were enrolled. Patients had pollakisuria and urinary incontinence associated with neurogenic bladder, nervous pollakisuria, unstable bladder, and irritable bladder (chronic cystitis and chronic prostatitis) or with urgency pollakisuria, and urgency incontinence associated with overactive bladder. Patients had to have had at least 4 weeks of treatment with another anticholinergic, which was discontinued due to lack of efcacy as determined by the treating clinician. Administration method and follow-up Patients were given 20 mg of propiverine hydrochloride once daily after meals, but the dosage could be adjusted based on age and symptoms, and the dose could be increased to 20 mg twice daily if necessary. Adverse Events The table below shows the most common adverse drug reactions and numbers of subjects discontinued from treatment Evaluation of Usefulness of Propiverine Hydrochloride in Poor Responders to Previous Anticholinergics
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